化学
脱氧核糖核苷
立体化学
核苷
脱氧核糖核酸
糖基化
核糖核苷
试剂
衍生工具(金融)
阿拉伯糖
有机化学
生物化学
核糖核酸
木糖
酶
经济
金融经济学
基因
发酵
作者
Chunyu Liu,Yu Chen,Xuebiao Pan,Fa-Zhan Liang,Z. S. Liu
出处
期刊:Tetrahedron
[Elsevier]
日期:2023-07-01
卷期号:141: 133515-133515
被引量:2
标识
DOI:10.1016/j.tet.2023.133515
摘要
An alternative synthesis of 3′-deoxy-3′-fluoro-d-ribofuranosyl nucleoside from d-arabinose is disclosed. Inversion of configuration at C3 on d-arabinoside promoted by DAST reagent is utilized to form lyxo-configured furanoside. After a sequence of fluorination, acidic methanolysis, triflation and displacement by -OBz. 3′-deoxy-3′-fluoro-d-ribofuranoside is obtained, which is then transformed to 1-O-benzoyl derivative. The synthesis of three 3′-deoxy-3′-fluoro-d-ribofuranosyl nucleosides, which can be served as fragment of antitumor active cyclic dinucleotide is finally completed through Vorbrüggen glycosylation .
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