KO t Bu-Promoted Synthesis of N -Triazolyl Alkylamide Derivatives

Herein, we report a strategy for the rapid synthesis of N-triazolyl alkylamides via a KO^tBu-promoted three-component reaction. The reaction proceeded via the cycloaddition of nitriles and azides in the presence of a base, followed by the capture of triazolamine and a triazole nitrogen anion intermediate with oxime esters. This protocol features broad functional group compatibility, mild reaction conditions, and late-stage functionalization of bioactive molecules.