乙烯基
激进的
化学
废止
催化作用
试剂
光化学
卡宾
组合化学
药物化学
有机化学
作者
Wenchang Li,Peng Zhou,Qi Zhao,Kejun Lin,Tingshun Zhu
摘要
An N-heterocyclic carbene-catalyzed cascade [3 + 2 + 1] annulation to assemble vinyl azides, aldehydes, and trihalomethyl reagents (Togni's reagent or CCl4) towards 1,3-oxazin-6-ones was reported. The cascade was triggered by an NHC-catalyzed single electron transfer (SET) between aldehydes and trihalomethyl reagents, followed by the addition of trihalomethyl radicals to vinyl azides, a denitrogenated transformation into iminyl radicals, a C-N radical coupling of iminyl radicals and ketyl radicals, and a base-controlled dehalogenative cyclization.
科研通智能强力驱动
Strongly Powered by AbleSci AI