锁(火器)
计算机科学
钥匙(锁)
计算生物学
纳米技术
食源性病原体
生化工程
生物
工程类
细菌
计算机安全
单核细胞增生李斯特菌
材料科学
遗传学
机械工程
作者
Xiaojing Liu,Deepak Kukkar,Ziai Deng,Dayong Yang,Yongsheng Ni,Ki‐Hyun Kim,Daohong Zhang
标识
DOI:10.1016/j.bios.2023.115317
摘要
In light of severe health risks of foodborne pathogenic bacterial diseases, the potential utility of point-of-care (POC) sensors is recognized for pathogens detection. In this regard, lateral flow assay (LFA) is a promising and user-friendly option for such application among various technological approaches. This article presents a comprehensive review of "lock-and-key" recognizer-encoded LFAs with respect to their working principles and detection performance against foodborne pathogenic bacteria. For this purpose, we describe various strategies for bacteria recognition including the antibody-based antigen-antibody interactions, nucleic acid aptamer-based recognition, and phage-mediated targeting of bacterial cells. In addition, we also outline the technological challenges along with the prospects for the future development of LFA in food analysis. The LFA devices built based upon many recognition strategies are found to have great potential for rapid, convenient, and effective POC detection of pathogens in complex food matrixes. Future developments in this field should emphasize the development of high-quality bio-probes, multiplex sensors, and intelligent portable readers.
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