Calcitonin Gene‐Related Peptide (CGRP)‐Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain‐Induced Sleep Disturbances

pathways, the terminals are then optogenetically silenced post-AIP and found the reversal of sleep disturbances in the following descending order of effectiveness: substantia innominata of the basal forebrain (SI-BF) > central nucleus of the amygdala (CeA) > bed nucleus of the stria terminalis (BNST) > the lateral hypothalamus (LH). In SI-BF and CeA, a similar reversal of AIP-induced sleep loss occurred with pharmacological blocking of either CGRP or NMDA receptors. The results are relevant to emerging pain therapies aiming to attenuate sleep disturbances.