PPP2/PP2A-mediated dephosphorylation of LC3B links PINK1-PRKN/Parkin-mediated mitophagy to SCA12 pathogenesis

: AO: antimycin A and oligomycin A; DFP: deferiprone; EGFP: enhanced green fluorescent protein; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; OPTN: optineurin; PINK1: PTEN induced kinase 1; PLA: proximity ligation assay; PPP2: protein phosphatase 2; PPP2CA: protein phosphatase 2 catalytic subunit alpha; PPP2CB: protein phosphatase 2 catalytic subunit beta; PPP2R2Bβ2: protein phosphatase 2 regulatory subunit B beta 2; PRKN/Parkin: parkin RBR E3 ubiquitin protein ligase; SCA12: spinocerebellar ataxia type 12; WT: wild type.