A Convenient Method for the Removal of Tetrabutylammonium Salts from Desilylation Reactions

Abstract This chapter describes a convenient method for the removal of tetrabutylammonium salts from desilylation reactions. One especially useful reagent for the removal of silyl protecting groups is tetrabutylammonium fluoride. The solubility of this reagent in organic solvents, as well as its chemoselectivity, has contributed to its frequent usage in the removal of silyl protecting groups. The chapter presents some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. It also describes the hazards associated with working with chemicals and the ways to deal with these hazards.