A patient with primary biliary cirrhosis and ulcerative colitis with progression to primary sclerosing cholangitis and colorectal cancer: A case report

Introduction: Ulcerative colitis (UC) is a chronic inflammatory disease of the colon characterized by intermittent exacerbations and remissions. It can be associated with primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC) and complicated with colorectal cancer (CRC). We describe a complicated case of associaton of PBC and chronic UC, eventually progressed to PSC and CRC. Case report: A 41­year­old female was diagnosed as PBC based on liver biopsy 10 years ago, and then UC was diagnosed too. Now symptoms of jaundice and abdominal pain aggravated. At last PSC and CRC were conformed. Conclusion: Prolonged Inflammatory bowel disease (IBD) accompanied with PSC in a patient has high risk of CRC. More exploration is needed to gain insight into relationship between IBD, PBD, PSC and CRC.