Overcoming Steric Constraints in C-H Arylation via Pd/Ag Dual Catalysis: A Shortcut to Ortho-Tetrasubstituted Heterobiaryl N-Oxides

The selective C-H arylation of N -containing aromatics with sterically demanding 2,6-disubstituted arylating reagents represents a straightforward way for the modular synthesis of ortho -tetra-substituted heterobiaryls, yet has remained scarcely explored due...