A series of 1,5‐benzothiazepine derivatives bearing quinoline moiety were obtained by 1,5‐benzothiazepine containing 2‐phensulfanyl‐quinoline ( 4a , 4b , 4c ) with equimolar amounts of benzohydroximinoyl chlorides 5 in CH 2 Cl 2 at room temperature. Structures of new compounds were confirmed by elemental analysis, IR, 1 H‐NMR, MS, and X‐ray diffraction analysis.