透明质酸
自愈水凝胶
生物相容性
胶粘剂
粘附
组织粘连
化学
化学工程
伤口敷料
伤口愈合
材料科学
纳米技术
高分子化学
有机化学
外科
复合材料
解剖
工程类
图层(电子)
医学
作者
Qi-Hang Yu,Chen-Ming Zhang,Zhiwei Jiang,Si‐Yong Qin,Aiqing Zhang
标识
DOI:10.1002/gch2.201900068
摘要
Hyaluronic acid (HA)-based hydrogels have been receiving increasing attention for wound management. However, pure HA hydrogels usually exhibit weak mechanical strength and poor anti-infection. Herein, a hybrid HA-based hydrogel (PDA-HA) comprised of polydopamine (PDA) and thiolated hyaluronic acid (HA-SH) is developed based on the Michael addition reaction. The introduction of PDA into HA hydrogel can decrease the critical gel concentration, improve the cell affinity and tissue adhesion, as well as endow the hydrogel with efficient free-radical scavenging ability. Combining the merits of good biocompatibility and moist environment from HA hydrogel with excellent tissue adhesiveness and free radical scavenging capability from PDA, this cross-linked PDA-HA hybrid hydrogel exhibits great potential for creating antimicrobial wound medical dressings.
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