CYP2E1
非酒精性脂肪肝
病态的
医学
发病机制
脂肪肝
疾病
机制(生物学)
内科学
生物信息学
药理学
生物
细胞色素P450
新陈代谢
认识论
哲学
作者
Kaiyue Wang,Wangxiao Tan,Xiao Liu,Li Deng,Lu Huang,Xiaoying Wang,Xiumei Gao
标识
DOI:10.1016/j.biopha.2021.111326
摘要
Over the years, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased year by year; however, due to its complicated pathogenesis, there is no effective treatment so far. It is reported that Cytochrome P450 2E1 (CYP2E1) plays an indispensable role in the development of NAFLD, and numerous studies have shown that flavonoids have a hepatoprotective effect and can exert a beneficial effect on NAFLD by regulating the activity of CYP2E1. Therefore, flavonoids may become effective drugs for the treatment of NAFLD in the future. This prompted us to review the research progress of the pathological mechanism of NAFLD and the impact of CYP2E1 activity changes during the pathological process, and to summarize the protective effect of flavonoids against CYP2E1 activity.
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