Antibacterial activities and cytocompatibility of zinc-contained strontium phosphate coating on titanium

Abstract Periprosthetic joint infection (PJI) is one of the most pivotal issues accounting for clinical failure of titanium (Ti)-based implants. Therefore, it is of great significance to develop an antibacterial coating with high biocompatibility on the Ti implant surface. In this article, a novel zinc-doped strontium phosphate coating, denoted as Sr-Zn-PCC, was deposited on Ti substrates by phosphate chemical conversion (PCC) method. The texture characterizations indicated that continuous coatings containing SrHPO 4 , Sr 3 (PO 4 ) 2 and SrZn 2 (PO 4 ) 2 phases were formed on the Ti surface. It is found that the doping of Zn could tune the surface microstructure, roughness, wettability and corrosion resistance of the coatings. The Sr-Zn-PCC coating showed the same bacterial adhesion property at short time (2 h), but tended to hinder biofilm formation on coatings after incubation for up to 24 h. Up to 80% of Staphylococcus aureus ( S. aureus ) were killed within 24 h by contact with the Sr-Zn-PCC surface. Moreover, cytocompatibility assay indicated that MC-3T3 cells had good adhesion, spreading properties on the coatings, suggesting that it is a promising alloy with both excellent antibacterial ability and high biocompatibility for the applications on orthopedic implants.