Facile synthesis of CDs@ZIF-8 nanocomposites as excellent peroxidase mimics for colorimetric detection of H2O2 and glutathione

[email protected] nanocomposites are designed and synthesized as nanoenzymes by a novel one-pot synthetic method in solvent-free system, in which ZIF-8 framework protects CDs from the aggregation and quenching, increasing the participation of CDs for catalytic reactions. The embedding of CDs into ZIF-8 matrix is conducted to rapid electron transfer, and their synergetic effect promotes the composite materials to have superior peroxidase-like activity. [email protected] materials have catalyzed the oxidation of a typical colorimetric substrate 3,3′,5,5′-tetramethylbenzydine (TMB) in the presence of H2O2 with the color changes from colorless to blue oxidized TMB (ox-TMB). A colorimetric approach could be established to detect H2O2 and glutathione (GSH) due to the outstanding peroxidase-like activity of [email protected] This work gives a feasible strategy for the synthesis of CDs-based composite nanozyme with enhanced catalytic activity and thus broadens the application of [email protected] materials in biological analytical field.