软骨
衰老
软骨细胞
再生(生物学)
化学
细胞生物学
氧化应激
软骨发生
解剖
生物
生物化学
作者
Lei Xu,Fenbo Ma,Jun Huang,Ka Li Frankie Leung,Chenghe Qin,William W. Lu,Xing Guo,Bin Tang
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2021-01-25
卷期号:22 (2): 671-680
被引量:20
标识
DOI:10.1021/acs.biomac.0c01488
摘要
Cartilage lesion is a common tissue defect and is challenging in clinical practice. Trauma-induced cellular senescence could decrease the chondrocyte capability of maintaining cartilage tissue regeneration. A previous investigation showed that, by controlling the cellular senescence, the cartilage regeneration can be significantly accelerated. Based on this finding, we design a novel hydrogel, Alg/MH-Sr, that combines metformin, an established drug for inhibiting senescence, and strontium, an effective anti-inflammatory material for cartilage tissue engineering. A RT-PCR test suggests the significant inhibitory effect of the hydrogel on senescent, apoptotic, oxidative, and inflammatory genes’ expression. Histological examinations demonstrate that the Alg/MH-Sr hydrogel accelerated cartilage repairment, and chondrocyte senescence was significantly inhibited. Our study demonstrates that the Alg/MH-Sr hydrogel is effective for cartilage defect treatment and provides a new clue in accelerating tissue repairment by inhibiting the senescence of cells and tissues.
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