化学
稻黄单胞菌
南方根结线虫
青枯菌
EC50型
生物测定
抗菌活性
柠檬黄单胞菌
体外
微生物学
细菌
生物化学
线虫
病菌
生物
生态学
基因
遗传学
作者
Chongfen Yi,Jixiang Chen,Chengqian Wei,Sikai Wu,Shaobo Wang,Deyu Hu,Baoan Song
标识
DOI:10.1016/j.bmcl.2019.126814
摘要
A series of α-haloacetophenones and analogues were synthesized. The bioassays show that some target compounds have good antibacterial activity against Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas axonopodis pv. citri (Xac) and Meloidogyne incognita (M. incognita). Especially, the compound 24 has good in vitro and in vivo antibacterial activities against Xoo, the EC50 value, curative and protection activities are 0.09 mg/L, 48.9%, and 52.3%, respectively, which are better than the thiodiazole copper and bismerthiazol. Meanwhile, the compound 24 has good in vitro antibacterial activity against Xac, and has an EC50 value of 1.6 mg/L. Moreover, the compound 19 exhibits good nematicidal activity M. incognita, with the LC50 value of 1.0 mg/L, which is better than the positive control avermectin. In addition, the compound 24 can inhibit the formation of extracellular polysaccharide and biofilm of Xoo, and change the permeability of cell membrane. α-haloacetophenone and analogues have the advantages of simple structure, high efficiency, broad spectrum of biological activity, and can be used as antibacterial agents and nematicides or lead compounds in the future.
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