CDKN2A
间皮瘤
融合基因
BAP1型
癌症研究
医学
癌基因蛋白质类
基因
生物
病理
遗传学
基因表达调控
作者
Fleur Cordier,Joni Van der Meulen,Nadine Van Roy,Jilke De Wilde,H Van Dijck,Filip Vanhoenacker,Marc Lambrechts,Valentin Noyez,Koen Van de Vijver,Liesbeth Ferdinande,Amélie Dendooven,Jo Van Dorpe,David Creytens
标识
DOI：10.1016/j.prp.2022.153772
摘要
Case report of malignant pleural mesothelioma with an ALK gene rearrangement, detected by FISH and confirmed by RNA-based next-generation sequencing. The co-occurrence of ALK gene fusions with the more common genetic alterations in CDKN2A, NF2 and BAP1 has, to our best knowledge, not yet been described in malignant mesothelioma. Furthermore, this unexpected finding could suggest a potential target for therapy in this subset of malignant mesotheliomas.
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