医学
多囊卵巢
胰岛素抵抗
血脂异常
内科学
妊娠期糖尿病
代谢综合征
疾病
糖尿病
2型糖尿病
2型糖尿病
内分泌学
亚临床感染
肥胖
怀孕
妊娠期
生物
遗传学
作者
Panagiotis Anagnostis,Basil C. Tarlatzis,Robert P. Kauffman
标识
DOI:10.1016/j.metabol.2017.09.016
摘要
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during their reproductive ages, associated with a plethora of cardiometabolic consequences, with obesity, insulin resistance and hyperandrogenemia playing a major role in the degree of such manifestations. These consequences include increased risk of glucose intolerance and diabetes mellitus (both type 2 and gestational), atherogenic dyslipidemia, systemic inflammation, non-alcoholic fatty liver disease, hypertension and coagulation disorders. Whether this cluster of metabolic abnormalities is also translated in increased cardiovascular disease (CVD) morbidity and mortality in later life, remains to be established. Data so far based on markers of subclinical atherosclerosis as well as retrospective and prospective cohort studies indicate a possible increased CVD risk, mainly for coronary heart disease. Future studies are needed to further elucidate this issue.
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