Heterogeneity of cortical breaks in hand joints of patients with rheumatoid arthritis and healthy controls imaged by High-Resolution peripheral Quantitative Computed Tomography 17 Chapter 3 Visual Detection of Cortical Breaks in Hand Joints: Reliability and Validity of High-Resolution peripheral Quantitative CT compared to MicroCT 31 Chapter 4 Vascular channels in metacarpophalangeal joints: a comparative histologic and high-resolution imaging study 45 Chapter 5 Development of a scoring method to visually score cortical interruptions on High-Resolution peripheral Quantitative Computed Tomography in rheumatoid arthritis and healthy controls 59 Chapter 6 Structural damage and inflammation on radiographs or MRI are associated with cortical interruptions on high-resolution peripheral quantitative CT: a study in finger joints of patients with rheumatoid arthritis and healthy subjects 75 Chapter 7 An automated algorithm for the detection of cortical interruptions on High Resolution peripheral Quantitative Computed Tomography images of finger joints 91 Chapter 8 Discussion and summary