类胰蛋白酶
肥大细胞
组胺
细胞培养
细胞
白血病
生物
全身性肥大细胞增多症
免疫学
细胞生物学
化学
生物化学
内分泌学
遗传学
作者
Joseph H. Butterfield,Deborah A. Weiler,Gordon W. Dewald,Gerald J. Gleich
标识
DOI:10.1016/0145-2126(88)90050-1
摘要
A cell line showing many characteristics of immature mast cells has been established from the peripheral blood of a patient with mast cell leukemia. Cultured cells contain low levels of histamine, are stained metachromatically by toluidine blue, and contain chloroacetate esterase, aminocaproate esterase and tryptase activities. The cells lack T and B lymphocyte, as well as myeloid cell markers, and do not possess IgE receptors. Solid tumors of metachromatically positive cells have been successfully induced and serially passed in nude mice using 5-azacytidine transformed cells. This cell line may be useful for future studies of mast cells and their constituents.
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