A MRI compatible optical system and its respiration adaptive estimation method for hemoglobin concentration in mice brain

We propose a design of a integrated system of optic fibers and a superconducting surface coil. A MRI compatible support fixed the optic fiber and the coil, and the optic fibers installed through the air gap. In order to compensate the periodic errors of the hemoglobin concentration estimation produced by the respiration and heart rate of subjects, we propose the generalized least square method to acquire the adaptive estimation, which considers the noise variance of the temporal optical measurements as a time-varying model. The vivo experiments that the optical-sensing simultaneously working with MRI scans are conducted to characterize the performance of this approach.