Determination of Camphor,Menthol and Borneolum Syntheticum in Cataplamat Devices by GC

Objective To establish a method for determination of camphor,menthol and borneolum syntheticum in cataplamat devices by GC.Methods The Alltech EC-WAX column(30 m ×0.53 mm,1.2 μm)was applied in the analysis with nitrogen as carrier gas and FID as detector.The temperature was programmed from initial column temperature at 85 ℃ for 1 minute,rose to 140 ℃ at the rate of 10 ℃·min-1 for 13 minutes and from 140 ℃ to 210 ℃ at the rate of 50 ℃·min-1 for 3 minutes.The detector temperature was 280 ℃ and injector temperature was 250 ℃.Results The linear relationship was good within the range of 8.7-4 355.0 μg·mL-1 for camphor(r=0.999 9),9.9-4 956.0 μg·mL-1 for menthol(r=0.999 9),and 10.0-4 998.0 μg·mL-1 for borneolum syntheticum(r=0.999 8).The average recoveries of camphor,menthol and borneolum syntheticum were 104.1%(RSD=2.7%),100.6%(RSD=2.4%) and 99.8%(RSD=2.6%),respectively.Conclusion The method is simple,sensitive,accurate,rapid,and can be applied to the determination of camphor,menthol and borneolum syntheticum in cataplamat devices.