There are a lot of noninvasive methods to diagnose coronary heart disease,In terms of the stressfull myocardial perfusion imaging,it includes exercise test and pharmacological test.According to analyze a lot of materials it believes adenosine lead to dilate coronary artery through some mechanism and that is the basis of myocardial perfusion imaging.Moreover,adenosine have a little side effect and shot half-life and high sensitivity and speciality.So it is thought clinically the most reliable noninvasive diagnosing method.Wether adenosine combined with different imaging agent(Tc99m-sestimibi and Tc99m -Tetrofosmin) can improve the diagnostic rate in myocardial perfusion imaging,it is discussed in the future.