Impact of dopamine and norepinephrine on the hemodynamics of dogs suffering from endotoxic shock

Objective:To observe the effects of dopamine(DA) and norepinephrine(NE) on the hemodynamics in endotoxic shock dog.Methods:Endotoxic shock model of dog was established by injection of lipopolysaccharide(LPS) intravenous.The hemodynamic parameters were assayed.Results:The mean artery pressure(MAP),cardiac index(CI),stroke volume index(SVI),systemic vascular resistance index(SVRI),left ventricular stroke work index(LVSWI),and right ventricular stroke work index(RVSWI) were decreased significantly after endotoxic shock.LVSWI and RVSWI were increased after NE treatment or DA combined NE treatment,but they were decreased after DA treatment.Conclusions:LPS has a direct influence on the systemic resistance blood vessel.DA cannot improve the cardiac function during the endotoxic shock.So,DA and NE are the best combination to improve on the cardiac function of dogs suffering from shock.