A clinical comparative study of paroxetine combined with buspirone in the treatment of depression

Objective To explore the efficacy and side effects of paroxetine combined with buspirone in the treatment of depression.Methods A total of 80 patients meeting the criteria of CCMD-3 for depression were randomly assigned to two groups.One group was treated with paroxetine and the other was with a combination of paroxetine and buspirone for 4 weeks of treatment.The efficacy was measured with Hamilton Depression Scale(HAMD)and Hamilton Anxiety Scale(HAMA).The side effects were evaluated with the Treatment Emergent Symptoms Scale(TESS).Results The reduction rates of HAMD scores in study group were significantly higher than those in control group on the 2nd and 4th weekend.The reduction rates of HAMA scores in study group were significantly higher than those in control group from the first weekend.The two groups had less side effects and the difference was not found between two groups.Conclusion It is suggested that the effect of paroxetine combined with buspirone is better and feasible to treat depression,especially for patients with anxiety.