The functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination

• Summarize the functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination . • Summarize the linkage types of non-degradative ubiquitination. • Propose the deficiencies of current research and the directions of future research. Ubiquitination of substrates usually have two fates: one is degraded by 26S proteasome, and the other is non-degradative ubiquitination modification which is associated with cell cycle regulation, chromosome inactivation, protein transportation, tumorigenesis, achondroplasia, and neurological diseases. Cullin3 (CUL3), a scaffold protein, binding with the Bric-a-Brac-Tramtrack-Broad-complex (BTB) domain of substrates recognition adaptor and RING-finger protein 1 (RBX1) form ubiquitin ligases (E3). Based on the current researches, this review has summarized the functions and effects of CUL3-E3 ligases mediated non-degradative ubiquitination.