The molecular electrostatic surface potential approach has been employed as an efficient tool in recent years to provide insight into the electrophilic and nucleophilic regions localized on atoms in molecules. Arpita Varadwaj, Pradeep R. Varadwaj, and Bih-Yaw Jin (DOI:10.1002/qua.24877) use this method and the results of several other first-principles approaches (e.g., quantum theory of atoms in molecules and noncovalent interaction reduced density gradient, etc.) to demonstrate that the fluorine's electrostatic surfaces along the outer C—F covalent bond extensions in tetrafluoromethane are weakly positive, which upon interaction with negative sites on another molecules can lead to the emergence of supramolecular complexes.