期刊:Chemical Communications [The Royal Society of Chemistry] 日期:2015-09-24卷期号:51 (80): 14929-14932被引量:26
标识
DOI:10.1039/c5cc04952k
摘要
A novel palladium catalyzed hydroxylation of unactivated aliphatic C(sp(3))-H bonds was successfully developed. Different from conventional methods, water serves as the hydroxyl group source in the reaction. This new reaction demonstrates good reactivity and broad functional group tolerance. The C-H hydroxylated products can be readily transformed into various highly valuable chemicals via known transformations. Based on experimental and theoretical studies, a mechanism involving the Pd(II)/(IV) pathway is proposed for this hydroxylation reaction.