硫脲
天然产物
胍
试剂
化学
组合化学
尿素
功能群
分子
有机化学
聚合物
作者
Thomas Suhs,Burkhard König
出处
期刊:Mini-reviews in Organic Chemistry
[Bentham Science]
日期:2006-11-01
卷期号:3 (4): 315-331
被引量:42
标识
DOI:10.2174/157019306778742841
摘要
The guanidinium group is a typical functional group in molecules with physiological or biological activity. Its geometry and physiochemical properties are of importance for molecular recognition processes. We discuss in this review modern synthetic methods for the introduction of the guanidinium group and focus our survey on examples from natural product synthesis and drug synthesis. The presented methods are sufficiently mild and selective to allow guanidylation of more complex structures. Keywords: Guanidinium, urea, thiourea, guanidinylation reagents, natural products, drug synthesis
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