Conformation-Transformable, Spiked Polypeptide Enables In Situ Cancer Vaccination via Conditional Antigen Capture and STING Activation

formed nanovaccine elicited robust antitumor immunity to inhibit tumor growth and recurrence in B16F10 tumor-bearing mice. This study represents an enlightened paradigm for constructing personalized cancer vaccines, and the control over polymer conformation, realized via the manipulation of chain rigidity and flexibility, provides a distinctive design strategy to regulate the interactions with biomacromolecules.