The association of lipoprotein-associated phospholipase A2 with cerebral white matter hyperintensity and dizziness in patients with cerebral small vessel disease

CSVD-related periventricular WMH is closely associated with pro-inflammatory factors and vascular risk factors. LP-PLA2 may induce demyelination changes in the periventricular region by disrupting the blood-brain barrier permeability. Periventricular demyelination affects the neural functional network involved in balance, leading to the occurrence of chronic dizziness. Additionally, LP-PLA2 serves as an adjunctive biomarker for risk stratification, facilitating the prioritization of vestibular evaluations and fall prevention strategies in the CSVD population.