WCN26-8040 IMPACT OF TREATMENT WITH NEFECON ON SERUM BIOMARKERS OF GUT-ASSOCIATED LYMPHOID TISSUE FUNCTION IN PATIENTS WITH IMMUNOGLOBULIN A NEPHROPATHY FROM THE PHASE 3 NEFIGARD TRIAL

Dysregulation of the gut-kidney axis is believed to play a pivotal role in the pathogenesis of immunoglobulin A nephropathy (IgAN). Genome-wide association studies have identified multiple risk alleles associated with development of IgAN, many of which are involved in the synthesis of immunoglobulin A (IgA) within the gut-associated lymphoid tissue (GALT). Furthermore, IgA generated at mucosal surfaces shares many of the physicochemical properties characteristic of mesangial IgA deposits and is enriched in circulating IgA immune complexes.