Gold(I)-Catalyzed Intermolecular Reactions of Alkynes with Carbon Nucleophiles: What We Know─and What We Don't

We present an overview of the scope, limitations, and challenges associated with gold-(I)-catalyzed intermolecular reactions involving alkynes and alkenes, or alkynes with other alkynes, as well as mechanistically related transformations with a broader range of carbon-based nucleophiles. Emphasis is placed on reactivity patterns, selectivity issues, and the factors that currently limit the generality and synthetic applicability of these processes.