薯蓣皂甙元
化学
腺癌
赫拉
细胞培养
激素
类固醇
细胞
药理学
癌症研究
生物化学
癌症
内科学
生物
医学
有机化学
遗传学
作者
Lin Wang,Maoling Yao,Yuegao Hu,Congdi Chen,Liming Jin,Xiaodong Ma,Hongjun Yang
标识
DOI:10.1021/acsmedchemlett.1c00581
摘要
Diosgenin, a component separated from Dioscorea plants, is an important starting material for steroid hormone drugs and semisynthetic steroids. In the work, two series of diosgenin derivatives were designed, synthesized, and evaluated for their cellular anticancer activities. Most of the target compounds exhibited good inhibitory activities against four cell lines, Aspc-1 (human colon adenocarcinoma cells), H358 (human nonsmall cell lung cancer cells), HCT116 (human colorectal adenocarcinoma cells), and SW620 (human metastatic pancreatic cancer cells). Among them, the representative compound 2.2f exhibited 7.9-341.7-fold antiproliferative activities against the above-mentioned four cell lines compared with the lead compound diosgenin.
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