功能磁共振成像
重性抑郁障碍
静息状态功能磁共振成像
默认模式网络
神经科学
前额叶皮质
背外侧前额叶皮质
心理学
认知
图论
医学
数学
组合数学
作者
Ming Ye,Tianliang Yang,Peng Qing,Xu Lei,Jiang Qiu,Guangyuan Liu
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2015-09-01
卷期号:10 (9): e0133775-e0133775
被引量:118
标识
DOI:10.1371/journal.pone.0133775
摘要
Recent developments in graph theory have heightened the need for investigating the disruptions in the topological structure of functional brain network in major depressive disorder (MDD). In this study, we employed resting-state functional magnetic resonance imaging (fMRI) and graph theory to examine the whole-brain functional networks among 42 MDD patients and 42 healthy controls. Our results showed that compared with healthy controls, MDD patients showed higher local efficiency and modularity. Furthermore, MDD patients showed altered nodal centralities of many brain regions, including hippocampus, temporal cortex, anterior cingulate gyrus and dorsolateral prefrontal gyrus, mainly located in default mode network and cognitive control network. Together, our results suggested that MDD was associated with disruptions in the topological structure of functional brain networks, and provided new insights concerning the pathophysiological mechanisms of MDD.
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