ASSOCIATION OF MACULAR STRUCTURE WITH MICROPERIMETRY SENSITIVITY FOLLOWING VITRECTOMY FOR PROLIFERATE DIABETIC RETINOPATHY

Purpose: To evaluate macular sensitivity using microperimetry in patients with proliferate diabetic retinopathy (PDR) following vitrectomy and to investigate the relationship between the sensitivity and foveal microstructures with optical coherence tomography/angiography (OCT/OCTA). Methods: Eighty-four eyes of 84 patients with PDR were included, who were indicated for vitrectomy, had no intraocular surgery history 3 months preoperatively, and were able to ensure fundus examination after the vitrectomy. A logMAR best-corrected visual acuity (BCVA), macular sensitivity of microperimetry, macular retinal thickness, and macular vessel perfusion using OCT/OCTA were examined at 1 week, 1 month, and 3 months postoperatively. Results: The LogMAR BCVA and mean macular sensitivity of PDR patients improved postoperatively (P < 0.05). There was a significant correlation between BCVA and mean sensitivity (P < 0.05). Postoperative mean macular sensitivity was significantly correlated with outer retinal thickness (ORT) in the 0-6mm macular area (P < 0.05), and also significantly correlated with deep capillary plexus (DCP) perfusion (P < 0.05). Fixation stability and mean macular sensitivity didn’t show any correlation with glycated hemoglobin (HbA1c), triglyceride (TG), Serum total cholesterol (TC), carbamide (URE), and creatinine (CRE), and duration of diabetes mellitus (DM) (P > 0.05). Conclusion: Postoperative mean macular sensitivity was significantly correlated with ORT and DCP perfusion for PDR patients. We found that the visual performance of patients can be evaluated by the ORT and DCP perfusion, so OCT/OCTA examination can be an important prognostic factor for visual performance in patients. Clinical Trial Registration: This trial is registered with the Chinese Clinical Trial Registry (http://www.chictr.org.cn, registration number ChiCTR2100043399).