Natural products-isoxazole hybrids: A review of developments in medicinal chemistry

Five-membered heterocycles containing nitrogen, oxygen atoms, especially isoxazoles, are widely present in many natural products and drugs and have relevant medical and pharmaceutical applications. Due to their rich biological activity, the development of novel isoxazole derivatives has been the focus of researchers and scientists. It is worth noting that a large number of isoxazoles have been used frequently as clinical drugs to treat various diseases, showing great development value and wide medicinal potential. In this review, the research progress of isoxazole natural products in anti-bacterial, anti-tuberculosis, anti-virus, anti-tumor, anti-inflammation, anti-diabetes, anti-parasite, anti-psychosis and other biological activities was reviewed. Finally, the research and development prospects of isoxazole natural products were prospected. This review will provide reference for the design of natural isoxazole products with stronger activity and less toxicity.