化学
催化作用
Strecker胺基酸合成
对映选择合成
组合化学
手性(物理)
分子
有机化学
手征对称性
物理
量子力学
夸克
Nambu–Jona Lasinio模型
作者
Yuhong Gao,Yuhong Gao,Yiqun Zeng,Tianran Deng,Yu Deng,Cheng Cheng,Jisheng Luo,Li Deng,Li Deng
摘要
Chiral aminonitriles not only are broadly useful building blocks but also increasingly appear as structural motifs in bioactive molecules and pharmaceuticals. The catalytic asymmetric synthesis of chiral aminonitriles, therefore, has been intensively investigated, as reflected in numerous reports of catalytic asymmetric Strecker reactions. Despite such great progress, the catalytic asymmetric synthesis of chiral α,α-dialkyl aminonitriles in a highly selective and efficient manner is still a formidable challenge. Here, we report a new approach for the catalytic asymmetric synthesis of chiral α,α-dialkyl aminonitriles via reaction of cyanoketimines with enals. We demonstrate that this reaction could be carried out with as low as 20 ppm catalyst loading.
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