Precise engineering of the biomolecular corona to accelerate the clinical translation of lipid nanoparticles

Abstract

Understanding and meticulously engineering the biomolecular corona on the surface of lipid nanoparticles can accelerate their successful clinical applications beyond mRNA vaccines. We outline the major hurdles of clinical development faced by lipid nanoparticles and discuss how considering and modifying the biomolecular corona could mitigate these challenges.