Preoperative localization of single gland disease in primary hyperparathyroidism: a comparative study for preoperative localization with four-dimensional computed tomography, ultrasonography, and technetium-99m-sestamibi single-photon emission computed tomography

In the preoperative localization of abnormal parathyroid lesions, 4D CT demonstrated higher sensitivity and specificity than US and ^99mTc-sestamibi SPECT. 4D CT can accurately localize abnormal parathyroid lesions, even in cases in which both US and ^99mTc-sestamibi SPECT yielded incorrect localizations.