Iridium-Catalyzed Asymmetric Hydrogenation of Tetrahydro-γ-Carboline: A Versatile Approach to Chiral cis-Hexahydro-γ-Carboline Derivatives Compatible with C6-Substituted Carbolines

An efficient iridium-catalyzed asymmetric hydrogenation (AH) of tetrahydro-γ-carboline has been developed for the synthesis of chiral cis-hexahydro-γ-carboline derivatives. This method overcomes the challenge posed by C6 substituents on the carboline...