创伤性脑损伤
注意事项
医学
眼底(子宫)
神经影像学
检测点注意事项
重症监护医学
急诊医学
病理
眼科
精神科
作者
Carl Banbury,Georgia Harris,Michael Clancy,Richard J Blanch,Jonathan James Stanley Rickard,Pola Goldberg Oppenheimer
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2023-11-17
卷期号:9 (46)
标识
DOI:10.1126/sciadv.adg5431
摘要
Traumatic brain injury (TBI), a major cause of morbidity and mortality worldwide, is hard to diagnose at the point of care with patients often exhibiting no clinical symptoms. There is an urgent need for rapid point-of-care diagnostics to enable timely intervention. We have developed a technology for rapid acquisition of molecular fingerprints of TBI biochemistry to safely measure proxies for cerebral injury through the eye, providing a path toward noninvasive point-of-care neurodiagnostics using simultaneous Raman spectroscopy and fundus imaging of the neuroretina. Detection of endogenous neuromarkers in porcine eyes’ posterior revealed enhancement of high–wave number bands, clearly distinguishing TBI and healthy cohorts, classified via artificial neural network algorithm for automated data interpretation. Clinically, translating into reduced specialist support, this markedly improves the speed of diagnosis. Designed as a hand-held cost-effective technology, it can allow clinicians to rapidly assess TBI at the point of care and identify long-term changes in brain biochemistry in acute or chronic neurodiseases.
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