石莼
安普克
多糖
肠道菌群
生物
拉图卡
化学
细胞生物学
生物化学
植物
磷酸化
蛋白激酶A
作者
Qiling Ruan,Yihan Chen,Jiahui Wen,Yinghui Qiu,Yajun Huang,Yi Zhang,Mohamed A. Farag,Chao Zhao
出处
期刊:Food Chemistry
[Elsevier]
日期:2023-05-01
卷期号:409: 135287-135287
被引量:5
标识
DOI:10.1016/j.foodchem.2022.135287
摘要
In this study, Ulva lactuca polysaccharide (ULP) antihyperglycemic effect was assessed by monitoring changes in the gut microbiota of aging diabetic mice. The results showed that ULP alleviated type 2 diabetes by improving insulin tolerance, increasing SOD and CAT activities, and thus lowering blood glucose level. Moreover, ULP regulated the expressions of INSR and AMPK concurrent with inhibition the expression of JNK, JAK, STAT3, p16 and p38 to improve glucose metabolism dysfunction. Interestingly, the abundance of Alloprevotella and Pediococcus change might the key factor for ULP antihyperglycemic effectiveness in aging-related diabetes. These results suggest that ULP can exert a mechanism of blood glucose regulation by improving intestinal diversity composition asides from direct insulin mimetic actions.
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