生物
细胞外基质
细胞外
真菌
细胞生物学
生物膜
枯草芽孢杆菌
微生物学
灰葡萄孢菌
调解人
真菌蛋白
菌丝
细菌
运动性
葡萄球菌炎
无礼的
细胞骨架
基质(化学分析)
芽孢杆菌(形态)
酵母
作者
Alicia Isabel Pérez‐Lorente,Carlos Molina‐Santiago,David Vela‐Corcía,Paolo Stincone,Jesús Hierrezuelo,Montserrat Grifé,Abzer Kelminal Pakkir Mohamed Shah,Antonio de Vicente,Daniel Petras,Diego Romero
标识
DOI:10.1093/ismejo/wraf277
摘要
Bacterial-fungal interactions have traditionally been attributed to secondary metabolites, but the role of the bacterial extracellular matrix in shaping these relationships has remained unclear. Here, we demonstrate that the extracellular matrix protein TasA is a key mediator in the antagonistic interaction between Bacillus subtilis and Botrytis cinerea. TasA enables Bacillus to tightly adhere to fungal hyphae, disrupts the β-glucan layer, and compromises fungal cytoskeletal integrity synergistically with fengycin, which causes cytological damage. Additionally, TasA acts as a carrier for bacillaene, amplifying its fungistatic activity. In response, Botrytis mounts a multifaceted defense, enzymatically degrading fengycin, producing antibacterial oxylipins, and activating adaptive programs such as hyphal branching and chlamydospore formation. Our findings reveal the previously unrecognized role of extracellular matrix components in fungal suppression and the modulation of fungal adaptive responses. This study reveals the complex interplay between microbial aggression and defense, providing new insights into the ecological dynamics of microbial competition and coexistence.
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