曲妥珠单抗
脑转移
医学
转移
乳腺癌
癌症
肿瘤科
血脑屏障
内科学
中枢神经系统
作者
Riccardo Soffietti,Alessia Pellerino
标识
DOI:10.1158/1078-0432.ccr-22-2853
摘要
Trastuzumab deruxtecan is a HER2-directed antibody-drug conjugate with ability to cross the blood-tumor barrier and activity on brain metastases. To test the activity of new drugs, patient-derived xenograft models from human brain metastases and phase 0 and window-of-opportunity trials are of utmost importance. See related article by Kabraji et al., p. 174.
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