拉曼光谱
化学机械平面化
信号(编程语言)
材料科学
干扰(通信)
微转移
纳米技术
生物医学工程
光学
图层(电子)
转移
计算机科学
癌症
医学
物理
内科学
频道(广播)
程序设计语言
计算机网络
作者
Kai Cui,Ruike Li,Yongming Zhang,Yuanyuan Qiu,Na Zhao,Yanna Cui,Wenwei Wu,Tize Liu,Zeyu Xiao
出处
期刊:Nano Letters
[American Chemical Society]
日期:2022-11-15
卷期号:22 (23): 9424-9433
被引量:1
标识
DOI:10.1021/acs.nanolett.2c03416
摘要
The intraoperative imaging applications of a large number of Raman probes are hampered by the overlap of their signals with the background Raman signals generated by biological tissues. Here, we describe a molecular planarization strategy for adjusting the Raman shift of these Raman probes to avoid interference. Using this strategy, we modify the backbone of thiophene polymer-poly(3-hexylthiophene) (P3HT), and obtain the adjacent thiophene units planarized polycyclopenta[2,1-b;3,4-b′]dithiophene (PCPDT). Compared with P3HT whose signal is disturbed by the Raman signal of lipids in tissues, PCPDT exhibits a 60 cm–1 blueshift in its characteristic signal. Therefore, the PCPDT probe successfully avoids the signal of lipids, and achieves intraoperative imaging of lymph nodes and tumor micrometastasis as small as 0.30 × 0.36 mm. In summary, our study presents a concise molecular planarization strategy for regulating the signal shift of Raman probes, and brings a tunable thiophene polymer probe for high-precision intraoperative Raman imaging.
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