This study introduces the concept of 'Hyperadaptor' alloys, materials engineered to maintain consistent performance across a wide range of environmental conditions. We present a Ni-based high-entropy alloy (HEA) that exhibits minimal sensitivity to temperature variations from 77 K to 873 K, maintaining both strength and ductility due to nano-sized L12 precipitates, coarse grain, and high stacking fault energy. The temperature-independent mechanism of dislocation slip-induced plasticity further supports its stability. Our findings highlight the potential of Ni-based HEA for demanding applications in aerospace, automotive, and energy sectors, establishing them as pioneering materials in alloy development.