生物相容性
海绵
伤口愈合
壳聚糖
锌
抗菌活性
止血
化学
材料科学
抗氧化剂
核化学
化学工程
生物医学工程
生物化学
有机化学
细菌
外科
医学
工程类
生物
植物
遗传学
作者
Qingwu Wang,Qiaoyi Han,Xin Xu,Dongdong Xu,Xiaojuan Nie,Xiaodong Xu,Xia Liu,Chunhong Zhang,Junqing Li,Qiang Shi
标识
DOI:10.1016/j.ijbiomac.2023.128960
摘要
Herein, a novel bioinspired radial porous zinc-based metal-organic framework (Zn-MOF) doped sodium alginate/chitosan derivatives/pullulan-based SA/PSCS/Pul/Zn-MOF (SPCP/Zn) composites sponge with excellent antioxidant and antibacterial properties was fabricated by the ice-templating method. Boric acid (BA) and Ca2+, which were respectively used as hydrogen- and ionic- bonding cross-linkers, provided strong mechanical properties for sponge matrix composed of SA, PSCS, and Pul. The obtained SPCP/Zn sponge exhibited uniform porous morphology, proper hydrophilicity, and admirable biocompatibility. In addition, the SPCP/Zn sponge achieved a sustained release of Zn2+ and gallic acid, which displayed powerful antibacterial and antioxidant activities. Importantly, the SPCP/Zn sponge exhibited shorter rapid hemostasis (20.4 ± 2.9 s) and lower blood loss (19.8 ± 4.3 mg). The SPCP/Zn sponge also showed faster wound closure ratio for the rat full-thickness skin defect model. It was revealed that SPCP/Zn sponge could significantly accelerate and enhance wound healing through downregulating inflammatory cytokines (TNF-α, IL-6) and increasing the expression of growth factors (VEGF). Due to its excellent properties, the SPCP/Zn sponge may have promising potential in wound healing applications.
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