Visible Light‐Driven Metal‐ and Photocatalyst‐Free Synthesis of β‐Trifluoromethylated Enamines via Trifluoromethyl Thianthrenium Salts

A novel protocol for the visible-light-driven synthesis of β-trifluoromethylated enamines has been developed, which operates without the use of transition metals or any photocatalysts, utilizing trifluoromethylthiosulfonium salts as the source of trifluoromethyl groups under mild conditions. According to this new protocol, more than 40 products have been prepared in moderate to good yields. In addition to eliminating the need for expensive or toxic transition metals and photocatalysts, this new methodology proves its potential scalability through air-stability, the use of safe and readily available reagents, a two-step one-pot procedure, and effective gram-scale reactions. This innovative approach not only demonstrates promise for green chemical synthesis but also offers a new pathway for the advancement of fluorine chemistry in sustainable organic synthesis.