化学
双功能
二乙胺
酰胺
亲核细胞
胍
盐(化学)
基础(拓扑)
碘化物
有机化学
催化作用
数学
数学分析
作者
Xifeng Shi,Takashi Ishihara,Hiroki Yamanaka,John T. Gupton
标识
DOI:10.1016/0040-4039(95)00076-o
摘要
β-Fluorovinamidinium salt (2), readily prepared fromN-(2, 3, 3-trifluoro-1-propenyl)trimethyl-ammonium iodide (1) and diethylamine, reacted with bifunctional hetero nucleophiles such as amidine and guanidine hydrochlorides in the presence of a base to afford regiospecifically monofluorinated pyrimidines4 in good yields. The one-pot procedure starting from1 was applicable for synthesizing heterocyclic compounds4 in almost comparable yields.
科研通智能强力驱动
Strongly Powered by AbleSci AI